| SCORES |
|---|
| Day | Date | | Opponent | Result | Location | Venue | Attendance |
|---|
| Sat | 8/9/2025 | A | San Francisco 49ers | 30-9 | W | | Santa Clara, CA | Levi's Stadium | 71124 |
| Sat | 8/16/2025 | H | Arizona Cardinals | 27-7 | W | | Denver, CO | Empower Field at Mile High | 62948 |
| Sat | 8/23/2025 | A | New Orleans Saints | 28-19 | W | | New Orleans, LA | Caesars Superdome | 70078 |
| Sun | 9/7/2025 | H | Tennessee Titans | 20-12 | W | | Denver, CO | Empower Field at Mile High | 73747 |
| Sun | 9/14/2025 | A | Indianapolis Colts | 28-29 | L | | Indianapolis, IN | Lucas Oil Stadium | 63910 |
| Sun | 9/21/2025 | A | Los Angeles Chargers | 20-23 | L | | Inglewood, CA | SoFiStadium | 70740 |
| Mon | 9/29/2025 | H | Cincinnati Bengals | 28-3 | W | | Denver, CO | Empower Field at Mile High | 75673 |
| Sun | 10/5/2025 | A | Philadelphia Eagles | 21-17 | W | | Philadelphia, PA | Lincoln Financial Field | 69879 |
| Sun | 10/12/2025 | A | New York Jets | | | | London, England | Tottenham Hotspur Stadium | |
| Sun | 10/19/2025 | H | New York Giants | | | | Denver, CO | Empower Field at Mile High | |
| Sun | 10/26/2025 | H | Dallas Cowboys | | | | Denver, CO | Empower Field at Mile High | |
| Sun | 11/2/2025 | A | Houston Texans | | | | Houston, TX | NRG Stadium | |
| Thu | 11/6/2025 | H | Las Vegas Raiders | | | | Denver, CO | Empower Field at Mile High | |
| Sun | 11/16/2025 | H | Kansas City Chiefs | | | | Denver, CO | Empower Field at Mile High | |
| Sun | 11/30/2025 | A | Washington Commanders | | | | Landover, MD | Northwest Stadium | |
| Sun | 12/7/2025 | A | Las Vegas Raiders | | | | Paradise, NV | Allegiant Stadium | |
| Sun | 12/14/2025 | H | Green Bay Packers | | | | Denver, CO | Empower Field at Mile High | |
| Sun | 12/21/2025 | H | Jacksonville Jaguars | | | | Denver, CO | Empower Field at Mile High | |
| Thu | 12/25/2025 | A | Kansas City Chiefs | | | | Kansas City, MO | Arrowhead Stadium | |
| Sun | 1/4/2026 | H | Los Angeles Chargers | | | | Denver, CO | Empower Field at Mile High | |
